Deuteros

Jan 8, 2019
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Hydrogen deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful technique for interrogating the conformational dynamics of proteins and their complexes. Currently, the downstream statistical analysis and visualisation of HDX-MS data from software such as DynamX (Waters Corporation, Manchester, UK) remains a laborious procedure, mainly due to the lack of streamlined methods to process large datasets. To remedy this, we developed Deuteros, a standalone graphical user interface written in MATLAB, designed to be coupled with Waters DynamX HDX data analysis software and allows rapid analysis and visualisation of data from differential HDX-MS.

Additional information can be found at: https://github.com/andymlau/Deuteros

HDX-MS Software
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Andy M. Lau
Structural Bioinformatician

I am a Research Fellow currently based at University College London with interests in predicting protein structure and behaviour using machine learning methods.

Publications

Deuteros 2.0: Peptide-level significance testing of data from hydrogen deuterium exchange mass spectrometry

Deuteros 2.0 features a repertoire of facilities for back exchange correction, data summarization, peptide-level statistical analysis …
Lau, A. M. C., Claesen, J., Hansen, K., Politis, A.
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Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry

We present Deuteros which is a standalone software designed to be coupled with Waters DynamX HDX data analysis software, allowing the …
Lau, A. M. C., Ahdash, Z., Martens, C., Politis, A.
PDF Project DOI